Fried brain sandwiches used to be a popular dish in the St. Louis area. They are still a local delicacy in Evansville, Indiana despite the stigma associated with mad cow disease (many restaurants replaced cow with pig brains).
American muffins are actually individual “quickbreads” or oil cakes (like zucchini bread), making them essentially cupcakes. English muffins are griddled flatbreads, which is why they are chemically and nutritionally more similar to pita or pizza than to American muffins.